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This high-risk game has a Pay Anywhere feature which rewards players with winnings when they get eight or more matching symbols anywhere on the reels. This game also features the Free Spins bonus with multipliers up to 500x your bet. A pragmatic trial that uses different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is necessary for pragmatic trials to be able to prove their validity and also helps to reduce bias in the results. However too much heterogeneity could lead to problems with the design of the trial. Pragmatic Play is also a major player in the live casino market, offering an extensive selection of classic table games such as Blackjack and Roulette in a variety of versions. The company's live studios in Romania and Malta provide a genuine gaming experience for its customers, as well as a full suite of virtual betting options. 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Legality Pragmatic Play has earned a name for itself by providing top-quality games and an outstanding user experience. The software is available on mobile devices and in multiple languages. Despite its relative youth it has already established itself as a top gaming platform for casinos. Wolves is one of the latest games, a 5-reel slot machine that has a high RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat. Pragmatic trials aim to mimic real-world situations and have the highest external validity. They are usually requested by practitioners and policy makers to guide their decision-making. They can be used to determine the cause-effect relationship of an intervention and its effects. They should, however, not be used to replace explanation studies. The concept of pragmatism is controversial, and there are questions about whether pragmatic trials can replace explanatory tests or if they should serve as an addition to them. Schwartz and Lellouch1 made the distinction between explanation studies, which prove a physiological hypothesis or clinical hypothesis, and pragmatic trials, that inform policy and practice decision-making. They also proposed an approach to pragmatic trials, dubbed PRECIS.2 This tool was designed to define the elements of a practical trial that include the recruitment process, the design and implementation of the intervention, as well as the follow-up. The number of pragmatic trials is increasing. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This is a sign that the health sciences community is becoming increasingly sensitized to the subject of pragmatism. It is important to note that the majority of these studies were conducted in primary care settings.